The underlying mechanisms involved in
allergic airway diseases are not fully understood, but our
knowledge has improved markedly in recent years. Allergens
activate airway epithelial cells and DCs to produce IL-1, IL-
25, IL-33, TSLP, GM-CSF, eicosanoids and danger signals
that are involved in the expansion and activation of type 2
innate lymphoid cells (ILC2) and activate DC migration to
lymph nodes where they instruct Th2 cell differentiation with
the help of IL-4 secreting basophils