Paw edema induced to produce acute inflammation
Carrageenan-, 5-HT-, and bradykinin-induced edema was
adopted as introduced by Winter, Risley, and Nuss 1962 with
slight modification by Ghosh and Singh.[16] Carrageenan 1%
in 0.9 % w/v sodium chloride was taken and 0.1 ml of this
solution was injected in subplanter region of hind paw of all
the rats of set A, one hour after the administration of the
drugs. The paw volume was measured after 1 hour and again
after 3 hours using a plethysmometer. Increase in volume
of paw edema was recorded by subtracting the initial paw
volume from final paw volume measured after 1 hour and
3 hours of carrageenan injection. Percentage of inflammation
rate was calculated as