Among the numerous garlic preparations available, aged black garlic extract (ABGE) is used as a major component of non-prescription tonics and dietary supplements (7). Compared to raw garlic, it has been shown to be more potent in many of the therapeutic properties of garlic, such as immunomodulative and antioxidative effects (8). In addition, ABGE, which is produced by a long-term extraction from garlic in aqueous ethanol, does not cause adverse events and has been confirmed to be safe in preclinical trials (9).