Before microbiological tests findings are available,
empiric therapy should be introduced.
Antibiotic therapy should include such broad spectrum antibiotics as ß-lactams and aminoglycosides.
When bacterially contaminated red blood cell concentrate transfusion- associated sepsis is suspected,
an antibiotic with anti-Pseudomonas activity should be introduced.
Then targeted antibiotic therapy should be started.
When a septic shock occurs,
shock-controlling procedures should include monitoring hemodynamics,
respiratory efficiency and kidney function.
In fluid resuscitation, crystalloids and natural or artificial colloid solutions are used.
The first transfusion consists of 500 – 1000 ml of crystalloids or 300 – 500 ml of colloids during 30 minutes,
and is repeated depending on such parameters as blood pressure, diuresis, and possibly volume overload.