Mutagenicity and Carcinogenicity Study
D-limonene elicited no mutagenicity in four
strains of S. typhimurium (TA98, TA100, TA1535, or
TA1537). Furthermore, no induction of chromosomal
aberrations or sister chromatid exchange in cultured
Chinese hamster ovary cells was observed.15 Additionally,
d-limonene did not contribute to cell mutations in
the liver or kidney of rats