The objective data are expressed as means ± standard deviation. The Wilcoxon signed-rank test, which is a nonparametric statistical hypothesis test, was used to compare the efficacy of 2% (w/w) GSSG lotion versus placebo lotion. SPSS 17.0.1 (SPSS Inc., Chicago, IL, USA) version was used for data analysis. All differences were considered significant at P,0.05.