systemic vasodilation characterized by a significant reduction in systolic blood pressure (SBP) ≥10 mmHg due to local mediators such as prostacyclin and nitric oxide (NO), in which the lowest blood pressure is reached at the gestational age of 22-24 weeks. This condition causes body adaptation by increasing the secretion of reninangiotensin aldosterone (RAA) that may lead to vasoconstriction, volume and plasma retention, as well as potassium excretion in the urine.