It will be hard to face food insecurity and malnutrition in sub-Saharan Africa without appropriate application offertilizers mainly organic fertilizers. Thus, for sustainable production of sesame (Sesamum indicum L.), aninvestigation on sawdust and poultry manure effects were conducted at Daloa. Four treatments (T0 = Control,T1 = Sawdust, T2 = Poultry manure, T3 = Sawdust + poultry manure) were tested in a randomized completethree blocks design. Statistical analysis indicated that treatment T3 boosted significantly growth, seed yield andits components. The fertilizing effect of poultry manure was superior to that of sawdust. The fertilizing effect ofthe mixture sawdust + poultry manure boosted seed yield and its components more than for sawdust and poultrymanure considered separately. A synergistic action between these two organic fertilizers is the basis of thateffect. This mixture is recommended to farmers