Considered a major force in the Op Art movement, Anuszkiewicz is concerned with the optical changes that occur when different high-intensity colors are applied to the same geometric configurations. Most of his work comprises visual investigations of formal structural and color effects, many of them nested square forms similar to the work of his mentor Josef Albers. In his series, "Homage to the Square," Albers experimented with juxtapositions of color, and Anuszkiewicz developed these concepts further. Anuszkiewicz has continued to produce works in the Op Art style over the last few decades.