The method is especially valuable in the pharmaceutical
industry for ionic analytes (in products containing non-ionic
components) that have little or no native UV absorbance.
However, the ability to couple the ion exchange separation with
numerous detection strategies expands IC applications to
instances were analyte-specific detection strategies can provide
the required degree of sensitivity and/or specificity. Utilization of
such strategies allows for IC applications to be implemented on
appropriately configured HPLC systems.