By profession, healthcare workers (HCWs) attend to clients and patients through a variety of preventive and curative services. However, while their attention is focused on providing care, they are vulnerable to hazards that could be detrimental to their health and well-being. This is especially true in developing countries where health service delivery is fraught with minimal protective precautions against exposures to numerous fomites and infectious agents. This study assessed the workplace hazards and safety practices by selected HCWs in a typical health care facility (HCF) in Nigeria.