(A) Exposure to CS for 3 week (C1), results in loss of endothelial cells and vacuolation of smooth muscles (thin arrow) of
media, increased adventitial thickness and presence of many mast cells (bi-head arrow). (B) Treatment with low dose antioxidants after
stopping exposure to CS (E1) results in marked improvement of endothelial lining (arrow) compared to the untreated group (C1). (C)
Treatment with high dose antioxidants after stopping exposure to CS (E2) results in relative improvement of the endothelial cells as some
cells are lost (arrow) and others are damaged (bi-head arrow) (H&E).