Subgroup analysis suggests that tabletop use of NSS, particularly saccharin, may be associated with bladder cancer (Annex 9: Fig. A9.35 and A9.36), although the differences between subgroups were not statistically significant for saccharin. Other significant associations were observed for NSS intake and increased risk of cancer of thelarynx and cancers not related to obesity,1 and decreased risk of cancer of the lung and ovary;however, only one or two studies contributed data to each of these results, so they must beinterpreted with caution.