To obviate such shortcoming, Peking iGEM developed a novel detection system, paired dCas9 (PC) reporter, that converts the sequence-specific information of pathogenic bacteria's genome (in our case, M. tuberculosis, MTB) into easily readable signal including bioluminescence, pigment, or electric current. Our PC Reporter was successfully applied to the detection of real pathogenic M.Tuberculosis H37Rv (isolated genomic DNA that is absolutely safe, prepared by our collaborator, not by us). Combined with our work in multiple-marker array (using MTB-specific markers extracted from the entire genome of MTB) and hardware development, our PC reporter system is expected to be a powerful tool in TB diagnosis, with a huge potential for various applications and extensions.