The in vivo study provides evidence that GBE significantly protected rats from neurotoxic effects of aluminum lactate as evidenced by restoration of normal brain AChE activity, lowered oxidative stress biomarkers, normalization of brain anti-oxidants’ content, and enhancement of memory function. Our results can open a window for prevention of this aluminum-caused neurotoxi-city by administration of GBE. Clinical studies are needed to provide further support of this conclusion and to investigate the ability to use such versatile herbal medicine in humans.