Methods: This descriptive cross sectional study was performed in 400 newborns under
mechanical ventilation in intensive care unit of a teaching hospital in Iran from April 2004 to December 2008.
Predisposing factors leading to ventilation and incidence of air leak syndromes were studied.
Sex, gestational age, birth weight, type of delivery, history of surfactant replacement
therapy, ventilator settings and mortality rate were recorded.
Statistical analysis was done usingSPSS software. Univariate analysis and regression analysis were considered.