The gene cluster consists of the lovastatin nonaketide synthase gene (lovB), lovastatin diketide synthase gene (lovF), enoyl reductase gene (lovC), transesterase gene (lovD), HMG-CoA reductase gene (ORF8), regulatory genes (lovEandORF13) which encodes a GAL4-like transcriptional factor and cytochrome P450 monooxygenase gene