Interestingly, the HR for incident T2DM increased in parallel with the score in all of the three studies, independent of the comparator chosen in each trial. For example, considering TNT and IDEAL studies, 80 mg atorvastatin was
associated with an increased risk of new-onset T2DM by 24% in patients with 2 to 4 risk factors. In any case, high dose therapy significantly re- duced the number of major CVD events [39