Gold nanoparticles are get medical attention because 1) Biocompatibility and 2) a chemical bond with the drug. Or substances like lead into the body. However, there are limits in the gold nanoparticles 1) the toxicity of gold nanoparticles and 2) half-life of gold nanoparticles, dependence the size, shape, ligends, and charge surface. The effects of gold nanoparticles interacting with cell membranes, or biomolecules in the body. It describes, in terms of size, shape, ligand and charge surface. Concluded that (1) gold nanoparticles uptake cell depend on the size, shape, ligand and charge surface (2) the critical ligands with cell type and surface properties of the gold nanoparticles (3) gold nanoparticles small size uptake cells faster than gold nanoparticles larger size. (4) gold nanoparticles that are small, they are likely to cause toxicity to the cells over a large gold nanoparticles. To study the interaction of gold nanoparticles with membrane will result in greater understanding. The chemical and physical properties of gold nanoparticles. The protective effect is due to the use of nanoparticles of various kinds in the future.