Methods based on mtDNA are highly sensitive. However, since the amount of mtDNA shows higher tissue-specific variation than nuclear DNA, quantification cannot be based on mtDNA instead a single copy chromosomal target is desirable
Methods based on mtDNA are highly sensitive. However, since the amount of mtDNA shows highertissue-specific variation than nuclear DNA, quantification cannotbe based on mtDNA instead a single copy chromosomal target isdesirable