leading to weaker binding of the guest. The better complexation
abilities of CRYMEB and RAMEB as compared to HP--CD could
be explained by the higher hydrophobic character of their cavity
due to the methylation of hydroxyl groups of the native CD that
favors inclusion complex formation (Danel et al., 2013). The assessment
of the binding ability of CDs toward EOs components allows
a better comprehension of interactions between CDs and EOs. This
could allow a versatile selection of the CD. In other terms, it leads
to a discrepancy in the release of EOs components: guests with
high Kf values will be released more slowly than those with low
Kf values. Here, we should note that, in addition to Kf value, guest
amount, volatility and solubility should also be taken into consideration
during the formulation of controlled release systems (Shiga
et al., 2003).