Pretreatment with formic acid, furfural,
acetic acid, 4-HB and levulinic acid to the cell mass significantly
improved the extraction and resulted in increases of 71%, 65%,
59%, 54% and 53% in lipid recovery, respectively, compared to
the untreated group. Furthermore, when the nine inhibitors
were mixed into the suspension at a 2-fold concentration of
their respective IC50 values, the lipid recovery was increased
by 78%, as compared with that of the untreated group. In view
of the data obtained in experiments using individual inhibitors,
the combination of the representative inhibitors resulted in
greater lipid recovery and synergistic positive effects on lipid
extraction.