Altogether, the data provide molecular clues on how ARFs can contribute to the specificity and selectivity of auxin responses through structural features, differential expression of family members at the tissue and organ levels and, ability to negatively or positively impact transcriptional activity of target genes. The auxin and ethylene regulation of some ARF members suggest their specific role in the multi-hormonal cross-talks. The regulation of the expression of ARFs by alternative splicing during fruit set provides new insight into the complexity of regulation of these genes at the post-transcriptional level.