The vast majority of yeast synthetic biology tools have been developed in S. cerevisiae due to its well-annotated genome, genetic tractability, and overall ease of use (Nielsen et al., 2013).
Likewise, the model yeast S. cerevisiae has historically dominated the arena of modified yeasts for industrial processing.
However, there are many other non-conventional yeast hosts with favorable traits (Buckholz and Gleeson, 1991; Gellissen et al., 2005), some of which are also used for industrial bioprocesses.
In particular, with advances in synthetic biology, non-conventional yeasts such as Hansenula polymorpha (syn.
Ogataea polymorpha), Kluyveromyces lactis, Pichia pastoris (syn. Komagataella pastoris), and Yarrowia lipolytica may take on expanded roles as industrial hosts.