The subacute phase of epidermal proliferation may be a process of dermal skin regeneration. If skin repeatedly undergoes UVB injury and regeneration, the cellular processes for control of epidermal homeostasis may be deregulated,thus initiating skin hyperplasia or carcinogenesis.
Moreover, it has been reported that in UVB-irradiated hairless mice, skin hyperplasia induces barrier disruption as indicated by expression of TEWL,