3. Skin Regeneration
3.1. Wound Healing
Skin regeneration and wound healing is a complex process,
which involves many cell types, such as epidermal, fibroblastic,
and endothelial cell, and various process such as proliferation,
cell migration, matrix synthesis, and contraction. In
embryos, wound healing involves repair processes that
BioFactors
142 Skin Regenerative Potentials of Curcumin
essentially result in perfect regeneration of damaged tissue [42].
The contribution of each cell types and how these signals control
wound cell activities during the healing in the skin is not well
defined. Inflammation and oxidative stress during wound healing
generally inhibits tissue remodeling. In healthy skin, superficial
wounds are expected to heal without incident whereas
wounds in chronically damaged or atrophic skin heal more
slowly and often lead to nonhealing ulcers with deadly consequences
[43].