Hyperbaric oxygen is a powerful treatment for acute and chronic wounds, acting on injured and healing tissue in a number of ways. Hypoxic tissue, reperfusion injury, compartment syndrome, crush injury, failing flaps, chronic wounds, burns and necrotizing infections have all been shown to respond favorably to HBO2. As we learn more about how HBO2 benefits wounds by up-regulating growth factors, down regulating cytokines, reducing edema, and supporting angiogenesis and new tissue ingrowth, the potential benefits to wound healing become clearer.