Cannabinoid receptors (CNRs) bind a class of lipid mediators, the endocannabinoids, that is involved in several physiological processes (e.g., food intake, memory, energy balance, immune system, and reproduction) [1–3]. In the past few decades, the increasing recreational use of cannabinoids such as marijuana and the potential negative health effects have reinforced public concern about these compounds. Cannabi- noid research received an initial boost from the characterization