LC–MS in combination with dispersive-SPE produced better selective and sensitive analysis of carbamate and OPPs pesticides in fruits and vegetables. It showed satisfactory validation results, such as accuracy, precision, and selectivity. For the pesticides studied, the sensitivity of the method developed was good enough to determine reliably at MRLs. It meets the requirement of quickness, simplicity, and economy for routine screening of pesticide residues and monitoring pesticide residues in the fruits and vegetables