After lumbar puncture, the NPY immunoreactivity in the CSFwas reported
to be higher in migraineurs during the attacks as compared with
controls (Valenzuela et al., 2000), whereas another research group did
not observe an NPY immunoreactivity elevation in the suboccipital
CSF or plasma during attacks and attack-free periods of patients with
migraine without aura (Vecsei et al., 1992). In migraine patients with
or without aura, the NPY immunoreactivity in the external jugular venous
blood did not alter duringmigraine attacks (Goadsby et al., 1990).