The third scenario adds TXA at high (99%) penetration and utilization to treat severe PPH only for women in hospitals, in addition to currently available interventions. In this scenario, the number of severe PPH cases did not change but the proportion of women who ultimately died from PPH was reduced. We estimate 1,394 maternal lives would be saved by this treatment. The fourth scenario evaluates TXA given as a treatment for severe PPH at home, clinic, and hospitals at high (99%) penetration and utilization. Again, the number of severe PPH cases has not changed, but the number of women who ultimately die is estimated to be reduced by 9,957 from the current care model because ∼85% of the deliveries in sub-Saharan Africa occur at home or community health clinics. In the fifth scenario, we modeled TXA use at home, clinic, and hospitals, but at more plausible rates of penetration and utilization, and the number of lives saved decreased nearly by half, compared with the previous scenario.