D4M.3A cells were injected intradermal into B6 mice (300 000 cells, per mouse). When tumors reached 5 mm in diameter (8 days post-injections), mice were either given drug-amixed chow containing PLX4720 (Plexxikon, Berkeley, CA) or control chow. Tumors were measured 4 and 7 days after the start of treatment and tumor volumes were calculated. After 7 days of treatment, mice that were fed the PLX4720 chow had significantly smaller tumors than mice that were fed the control chow (Figure 3B, P < 0.05). Mice injected with