6-Gingerol has been shown to inhibit the expression of
inducible nitricoxide(NO) synthase and production of NO
in mouse macrophages and suppress peroxynitrite- induced oxidation of 20,70-dichlorofluorescein
diacetate suggesting
that 6-gingerol could be apotent inhibitor of NO synthesis. It has also been suggested that 10-shogaol stimulates
nuclear accumulation of NF-E2-related factor 2 and subsequent up regulations of antioxidant response elementmediated antioxidant/detoxify in genzyme expressions Increases in antioxidant capacity can
reduce oxygen-derived reactants, collectively termed
reactive oxygen species, which aregenerated by the high energy demands and increase doxygen requirements of
milk synthesis and secretion