Our results suggest that exposure of embryos and early larval stages to elevated pCO2 and/or lowered pH may be particularly detrimental. However, this and other squid species dynamically migrate [47], [94] and encounter oceanographic regions of high CO2 during their lifetimes [76], [95]. Pacific Humboldt squid (Dosidicus gigas) are able to suppress their metabolism when vertically migrating through oxygen minimum zones [96]. Other squid, such as Vampyroteuthis infernalis, exist almost solely in these environments and thus are presumed to have vital rates adapted to higher CO2 and lower O2 levels [97]. The high reproductive output of most cephalopod species suggests that their potential for adaptation to a changing environment may be high. Results thus far suggest that there may be pCO2 threshold levels at which effects on cephalopod embryonic development time and size-at-hatching are demonstrated [41]. Indeed, some studies that have examined ocean acidification effects on older (i.e., juvenile) animals or that have used lower pCO2 levels have found no such effects [18], [42], [43]. The cephalopod calcification response to ocean acidification does not appear to follow a clear trend, which suggests that further investigations with other squid species under similar experimental conditions are required to determine the range of responses. Likewise, experiments across a range of CO2 concentrations will be needed in order to determine whether there are threshold ocean acidification levels for impacts on calcification rates in cephalopods.