Berries generally refer to small, brightly colored soft fruits, including strawberries, blueberries, cranberries, and others that are not very important economically. Berries are highly regarded on account of their attractive colors, unique flavors, delicate textures, and especially their numerous health benefits. Berries have attracted attention worldwide because of their well-known biological activities. Numerous investigations have indicated that consumption of berries can prevent or delay the onset of chronic age-related diseases, e.g., cardiovascular disorder, memory decline, eyesight fading, and cancer, owing to their antioxidant, anti-inflammatory, gastro-protective, and antimicrobial activities. Recently, increased consumption of berries has been associated with reduced risk of all-cause mortality and mortality related to cancer and stroke. These health-promoting effects of berries are largely attributed to their phenolic compounds; the most abundant of which are the anthocyanins. Nineteen naturally occurring anthocyanidins or aglycones have been detected; six of which are common in higher plants.