Along with enzymes, Bacillus subtilis also produces a toxin called subtilisin. Subtilisin can cause allergic reactions if there is repeated exposure in high concentrations. This only poses a risk to fermentation plants that use high quantities of subtilisin. Exposure restrictions have been imposed by OSHA for the factory setting and can be found on their website (Occupational Safety & Health Administration). Subtilisin is also used in laundry detergent. It has been known to cause allergic reactions after using such detergent, however only in large quantities.