This essay discusses random drug testing in schools. A brief introduction is followed by an expanded discussion on the positions of key stakeholders whose interests include economics, sports, academics, societal relationships, health care, the law, and the workplace. This article reveals that there are limitations to drug testing capability and room for detrimental errors. Finally, the author addresses how governmental support for robust drug prevention in children and adolescents is a priority in the White House today, but conclusions drawn and resultant policy-setting may be based more on anecdote than on statistically-qualified research