Adiponectin. Weight loss has been shown to increase adiponectin levels; in animal models of obesity and insulin resistance, its levels are reduced. Adiponectin regulates lipid and glucose metabolism, increases insulin sensibility, regulates food intake and body weight, and protects against chronic inflammation.Human studies show that hypoadiponectinemia is associated with insulin resistance, hyperinsulinemia, and the possibility of developing type 2 diabetes, independent of fat mass.