Pressurized liquid extraction (PLE), alsoknown as accelerated solvent extraction (ASE), emerged as analternative to the extraction and fractionation of natural products,through a clean technology and with the possibility of adjustingparameters to the selectivity of the process to a group of com-pounds to be extracted, which is a good option to add value toby-products of blueberry processing industries. PLE using wateras solvent is one of the most interesting methods, since water is non-toxic, non-flammable, environmentally safe, and inexpensive