Similar to the effects on adipose tissue, myostatin effects on bone may be direct or indirect.Specifically, the bone mass increase observed with myostatin/ActRIIB inhibition might be due to a direct bone effect, bycross-reactivity of a myostatin antagonist / ActRIIB decoyreceptor with the ActRIIA signaling cascade or indirect viaincreased mechotransduction due to the higher muscle mass /force applied to the bone