•Patch testing to standard and special series allergens should be performed in cases of prolonged leg ulcer healing. Clinicians should be aware that multiple reactions in the same patient are common. Of note, sensitivity to lanolin products is decreasing world-wide; however, there are reports of increasing sensitivity to new products containing certain hydrogels that form the basis of sustained-release topical drug delivery systems.
•Leg wounds treated with topical antibiotics may develop resistant organisms or sensitivities over time.