ABSTRACT: National research Institute for Earth science and Disaster prevention is constructing the world’s largest 3-D full-scale shake table which is nicknamed as “E-Defense”. In order to resolve several subjects for the utilization of E-Defense, NIED investigates the themes as follows, 1) Establishment of utilization and wide area network systems, 2) Development of 3-D ground motion database and a numerical simulation system for the shake table, and 3) Test and analysis of reinforced concrete structures, soil-pile-structure systems and wooden structures for using E-Defense.