caregiver burden refers to the subjective perceptions of caregivers about peronal strain and role strain. In this study, the researcher used the Zarit Burden interview development by Zarit, Reever, and Bach-Peterson (1980) and performed into Thai version by the MAPI Institute(2009) in France to assess the level of caregiver burden of advanced cancer patients' caregiver. A high score is indicative of a high level of caregiver burden