Recent developments in the management of mechanically
ventilated patients have improved the survival rate of
critically ill patients1–5). Survivors of prolonged mechanical
ventilation frequently suffer from long-term physical dysfunction6,
7). Early mobilization is a physiotherapy technique
that is usually initiated within one or two days following
endotracheal intubation and mechanical ventilation8), and
has been shown to be effective at preventing skeletal muscle
wasting and weakness in surviving patients9–12). The reported
clinical benefits of early mobilization of mechanically
ventilated patients are a decreased duration of mechanical
ventilation13, 14), reductions in the incidences of ventilatorassociated
pneumonia (VAP)15, 16) and intensive care unit
(ICU) delirium13), shorter ICU and hospital stays14, 17), and
improved functional status upon hospital discharge13). Despite
these reported clinical benefits, it remains controversial
Recent developments in the management of mechanicallyventilated patients have improved the survival rate ofcritically ill patients1–5). Survivors of prolonged mechanicalventilation frequently suffer from long-term physical dysfunction6,7). Early mobilization is a physiotherapy techniquethat is usually initiated within one or two days followingendotracheal intubation and mechanical ventilation8), andhas been shown to be effective at preventing skeletal musclewasting and weakness in surviving patients9–12). The reportedclinical benefits of early mobilization of mechanicallyventilated patients are a decreased duration of mechanicalventilation13, 14), reductions in the incidences of ventilatorassociatedpneumonia (VAP)15, 16) and intensive care unit(ICU) delirium13), shorter ICU and hospital stays14, 17), andimproved functional status upon hospital discharge13). Despitethese reported clinical benefits, it remains controversial
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