The reduction (50%) of goat's milk during the manufacture of Coalho cheese did not produce changes in the physicochemical (fat, protein, salt and pH) and instrumental texture, except for hardness that decreased. On the other hand, the replacement by cow's milk led to changes with respect to fatty acids profiles with a reduction in short fatty and linoleic acids and a slight increase of palmitoleic acid, which affected positively the sensory acceptance of mixture cheeses. Additionally, the color was also significantly changed by reducing the whiteness. The cheese made from a mixture of cow's and goat's milk consists of a differentiated dairy product, because it presented a diminished caprine taste, which contributes to better acceptance by consumers, nevertheless maintaining relevant positive nutritional properties of goat's cheese. Furthermore, this kind of cheese may be an alternative product for the Northeast region as the main goat milk and Coalho cheese producer region in Brazil.