being choline
chloride and acids the major choice for their preparation. Their potential
for the extraction could be ascribable to their great capacity to form
hydrogen bonds with the analytes. Considering the drawbacks of traditional
methodologies, mainly due to the extensive use of organic
solvents, NADES are a green option in this area. An additional advantage
is the possibility to produce tailor-made solvents compatible with
the chemical nature of the analytes under study. Physical properties
of NADES, such as polarity, viscosity and temperature have a great influence
in the extraction. The optimization of all the parameters by
multivariate analysis, and also the extraction parameters, is a powerful
tool to obtain the suitable results