Weight
Weight loss and low body mass index (BMI) are both associated with
increased risk of osteoporosis. Post-menopausal women with a BMI in
the lowest third carry twice the risk of osteoporosis of women in the
highest third. A very high BMI (>30 = obese) is less protective than
moderately elevated BMI (25-30 = overweight). The mechanisms underlying
the protective effect of weight are poorly understood but involve
cross-talk between signalling factors released by adipose tissue with
those regulating bone turnover