Recovery of platelet function measured with multiple-electrode aggregometry
(Multiplate) in individual horses at T240 compared with T0 (+, baseline value ±15%
achieved; −, baseline value ±15% not achieved)
The mean relative decrease in aggregation 6 h after clopidogrel
loading dose was 35 ± 20% measured by ADPtest and 36 ± 20% measured
by ADPtestHS. Nevertheless, full recovery of ADP-induced
platelet function after cessation of medication at T240 was achieved
in seven of 10 horses according to the ADPtest, but the ADPtestHS
revealed full recovery of the P2Y12-mediated platelet function in nine
of the horses