it is commonly recommended that men avoid retinoid therapy when actively trying to father children. Prescribing of isotretinoin in the U.S. is restricted via the risk-mitigation iPLEDGE system (Goldsmith et al., 2004). Serum lipid elevation is the most common laboratory abnormality. This may be due to increased expression of apolipoprotein C-III by systemic retinoids, which prevents the uptake of lipids from very-low-density lipoproteins into cells (Vahlquist et al., 2008).