The Zika virus is in the family Flaviviridae and genus Flavivirus has two lineages (Asia and Africa). Was first discovered in Uganda [1947], and the first human infection have been reported in Nigeria [1952]. In 2007, had epidemic of the Zika virus, from the Asian lineage on the island of Yap, Micronesia. Then, extend to French Polynesia and other regions of the South Pacific induce to widespread epidemics in 2013 and 2014, and in 2015 the outbreak of the Zika virus in South America as one of the most serious emergency cases and causing the outbreak, about 1.5 million estimated in the country of Brazil in 2015.